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Play Dr. Mario 64 (US edition) Online
Dr. Mario 64
Play Dr. Mario 64 online. Learn capsule movement and rotation, clear viruses in Classic and explore Story, Flash and Marathon puzzle modes.
Browser play

Nintendo 64 (N64) — EmulatorJS controls
Default Player 1 keyboard mapping. Change keys in Controller Settings.
| Console button | Keyboard |
|---|---|
| ↑ / ↓ / ← / → | ↑ / ↓ / ← / → |
| A / B | X / S |
| START | Enter |
| L / R | Q / E |
| Z | Tab |
| L-STICK ↑ / ↓ / ← / → | T / G / F / H |
| C ↑ / ↓ / ← / → | I / K / J / L |
Open Controller Settings to configure your keyboard or gamepad. Touch controls are available on mobile.
How to Play Dr. Mario 64
Quick start
Enter the single-player menu and choose Classic. Start with a low virus level and slow speed, then use the first capsules to extend matching colours beside a virus. Keep the bottle’s neck clear and practise rotation before accelerating the fall.
Controls
D-pad left/right: move the capsule; down: drop faster; A: rotate clockwise; B: rotate counterclockwise; START: pause. Match four or more pieces of one colour in a horizontal or vertical line to remove them.
Dr. Mario 64 — About this game
Dr. Mario 64 asks you to line up four or more matching capsule halves and viruses horizontally or vertically. Clearing a line can free pieces above it and create another match, but careless stacking blocks access to the remaining viruses. Classic focuses on clearing the bottle; Story turns the puzzle into a sequence of rival battles. Marathon keeps new viruses arriving, while Flash targets specific flashing viruses. Multiplayer brings the same placement decisions into competition for up to four players.
Dr. Mario 64 Game manuals
Cheats
No cheats have been added for this edition.
Player verification and sources
Browser play was reviewed before this edition was published in the catalogue. The date below is the catalogue publication date, not the game’s original release date.
- Browser test and catalogue publication date
- Browsers and devices
- PC: Chrome, Edge and Firefox. Mobile: Chrome on Android and Safari on iPhone and iPad.
- Player engine and core
- EmulatorJS 4.3.0-pre · n64
- Tested by
- rwEmulator
Sources and editorial basis
rwEmulator reviews edition metadata, release information, game manuals and first-hand browser-play notes. Available manuals are linked below; the editorial policy explains how facts are checked and corrections are handled.